Ionizable Lipids for LNP Research

Ultra-pure benchmark lipids, in stock and made to order

Peak Lipids supplies ultra-high-purity ionizable lipids for researchers developing lipid nanoparticle (LNP) formulations for mRNA, siRNA, and other nucleic acid therapeutics.

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≥98% Purity, N-oxide free

6 Ionizable lipids in stock

40+ yrs Pioneering LNP delivery

Our Lipids

Six ionizable lipids, in stock and made to order

Benchmark compounds used in FDA-approved drugs, alongside our novel nor-MC3 and nor-KC2 — each delivered as a clear oil of exceptionally high purity.

Structure drawing coming soon

Ionizable Lipid

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Why Purity Matters

High-performing LNPs begin with high-purity lipids

Oxidation products are among the most important impurities in ionizable lipids. They can react with encapsulated mRNA, reducing protein expression even when routine quality tests indicate the RNA remains intact. Starting with ultra-high-purity lipids helps minimize this source of variability and supports more reproducible research.

Packer et al., Nature Communications 2021

~50%

mRNA in an LNP chemically damaged after 3 months of refrigerated storage.¹

>60%

the purity a standard test still reported for that same mRNA. The damage is largely undetected by routine quality control.¹

Ranjbar et al., Journal of Controlled Release 2026

Up to 10%

lower purity than vendor reported purity based on an FDA study.²

Our Standard

Purity That Delivers

Every Peak lipid is a colourless oil, free of N-oxide and other detectable impurities, confirmed at ≥98% purity by LC-MS. We pack under argon to keep oxidation from setting in. The result is one less variable in your formulation.

≥98%

Purity by LC-MS, with no detectable N-oxide.

Colourless oilN-oxide freePacked under argon≥98% by LC-MS

Packer, M. et al. A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems. Nature Communications 12, 6777 (2021). doi.org/10.1038/s41467-021-26926-0
Ranjbar, S. et al. Impact of ionizable lipid source on quality and stability of siRNA-loaded lipid nanoparticles. Journal of Controlled Release 393, 114825 (2026). doi.org/10.1016/j.jconrel.2026.114825

Why Peak Lipids

Built by pioneers in ionizable lipid science

Decades of expertise in lipid nanoparticle technology inform every lipid we produce.

Dr. Pieter Cullis

Lipid Nanoparticle Pioneer

A leader in the LNP field for over 40 years. His work enabled five FDA-approved drugs — including Onpattro, Comirnaty, and Vincristine — collectively administered to billions of patients worldwide.

Dr. Marco Ciufolini

Lipid Design & Synthesis

A world leader in lipid design and synthesis, and inventor of KC2, nor-MC3, and nor-KC2. His work has contributed to the development of Masitinib, Triasorb, and Onpattro.

Dr. Ardalan Nabi

Senior Synthetic Chemist

A senior synthetic chemist specializing in organic synthesis and lipid chemistry. He designs, synthesizes, and optimizes lipid structures to enhance delivery and performance.

Custom Synthesis

Custom lipids, built to the same standard

We design and synthesize custom ionizable lipids to your specification, at the same purity as everything in our catalogue. Send us your requirements and we'll take it from there.

Discuss a custom synthesis

Ordering

Simple to order, shipped worldwide

Pricing is provided by quote — tell us what you need and we'll get back to you with availability and timelines.

01

How to Order

Request a quote with the lipid name, quantity, and your business details. We respond with pricing and availability.

02

Pack Sizes

Glass vials, 1g per vial, shipped on dry ice. Bulk pricing on orders of 5g or greater.

03

Lead Time

In-stock lipids ship within 5 business days. Custom and made-to-order compounds on request.

04

Shipping

Flat $100 rate. FedEx Priority to North America & EU, DHL to Asia & the Middle East.

05

Documentation

Every lot ships with a Certificate of Analysis, SDS, and lot-specific LC-MS data.

Request a Quote

Tell us about your requirements

Pick your lipid and quantity, add any details, and we'll respond promptly with pricing, availability, and timelines.