{"product_id":"kc2","title":"DLin-KC2-DMA","description":"\u003cp\u003eDLin-KC2-DMA, commonly known as KC2, was among the first ionizable lipids to achieve effective in vivo siRNA silencing at clinically relevant doses. It also provided an important foundation for the development of subsequent ionizable lipids, including MC3. Its structure comprises two linoleyl chains connected through a 1,3-dioxolane ring to a dimethylaminoethyl head group, providing the pH-responsive ionization required for efficient nucleic acid delivery.\u003c\/p\u003e\u003cp\u003eKC2 is supplied as a clear oil with a purity of ≥98%, verified by ¹H NMR, ¹³C NMR, and LC–MS. The material is free from detectable N-oxide impurities and is intended exclusively for research use. It is not suitable for human or veterinary applications.\u003c\/p\u003e\u003cp\u003eKC2 is widely utilized in siRNA and mRNA lipid nanoparticle (LNP) research as a delivery component and a reference lipid in structure–activity relationship studies (SAR), particularly in comparisons with MC3 and other ionizable lipid platforms. It is commonly used to evaluate how variations in lipid head-group chemistry and hydrophobic tail structure influence key delivery properties, including apparent pKa, nucleic acid encapsulation efficiency, and endosomal escape performance.\u003c\/p\u003e\u003cp\u003eDue to the presence of polyunsaturated lipid chains, KC2 is susceptible to oxidation and therefore requires careful storage and handling. To maintain product stability and quality, it is packaged under an argon atmosphere and supplied free of detectable N-oxide impurity.\u003c\/p\u003e","brand":"Polymorphic Lipids","offers":[{"title":"100 mg","offer_id":46550151954593,"sku":"PL-KC2-100MG","price":0.0,"currency_code":"CAD","in_stock":true},{"title":"1 g","offer_id":46550151987361,"sku":"PL-KC2-1G","price":0.0,"currency_code":"CAD","in_stock":true},{"title":"Custom","offer_id":46550152052897,"sku":"PL-KC2-CUSTOM","price":0.0,"currency_code":"CAD","in_stock":true}],"url":"https:\/\/peaklipids.com\/products\/kc2","provider":"Peak Lipids","version":"1.0","type":"link"}