{"product_id":"nor-kc2","title":"nor-KC2","description":"\u003cp\u003enor-KC2 is an ionizable cationic lipid structurally related to DLin-KC2-DMA (KC2), with the C18 linoleyl chains of KC2 replaced by shorter C17 chains. Like KC2, it features two hydrophobic chains connected through a 1,3-dioxolane ring to a dimethylaminoethyl head group.\u003c\/p\u003e\u003cp\u003eThe C17 chains are derived from commercially available methyl linoleate. This enables a shorter, more streamlined synthetic route than the original preparation of KC2. Published studies indicate that nor-KC2 can provide comparable or improved nucleic acid delivery performance relative to KC2.\u003c\/p\u003e\u003cp\u003enor-KC2 is used in siRNA and mRNA LNP formulation and in structure–activity work on ionizable lipid design, where the dioxolane scaffold makes it a useful counterpart to the ester-linked MC3 series. As with nor-MC3, the simpler synthesis is the practical draw: it makes the lipid easier to produce consistently and to scale up when a formulation moves beyond screening quantities.\u003c\/p\u003e","brand":"Polymorphic Lipids","offers":[{"title":"100 mg","offer_id":46550152315041,"sku":"PL-NORKC2-100MG","price":0.0,"currency_code":"CAD","in_stock":true},{"title":"1 g","offer_id":46550152347809,"sku":"PL-NORKC2-1G","price":0.0,"currency_code":"CAD","in_stock":true},{"title":"Custom","offer_id":46550152413345,"sku":"PL-NORKC2-CUSTOM","price":0.0,"currency_code":"CAD","in_stock":true}],"url":"https:\/\/peaklipids.com\/products\/nor-kc2","provider":"Peak Lipids","version":"1.0","type":"link"}