{"product_id":"sm-102","title":"SM-102","description":"\u003cp\u003eSM-102 is an ionizable cationic lipid used in lipid nanoparticle (LNP) formulations for mRNA delivery. Its structure comprises a tertiary amine bearing a hydroxyethyl substituent and two ester-linked lipid tails, one branched and one linear.\u003c\/p\u003e\u003cp\u003eThe amine remains predominantly neutral at physiological pH but becomes protonated under acidic conditions. This pH-dependent ionization supports efficient nucleic acid encapsulation during LNP formulation and promotes intracellular release following cellular uptake.\u003c\/p\u003e\u003cp\u003eSM-102 is the ionizable lipid used in Moderna's COVID-19 mRNA vaccine and is widely recognized as a benchmark in mRNA–lipid nanoparticle (LNP) research. It is commonly used in mRNA vaccine development, the delivery of protein-replacement and gene-editing payloads, and comparative studies evaluating the performance of ionizable lipids.\u003c\/p\u003e\u003cp\u003eSimilar to ALC-0315, SM-102 contains saturated lipid tails, which makes it less susceptible to oxidative degradation along the hydrocarbon chains. As a result, the primary oxidative impurity of concern is the formation of the amine N-oxide rather than chain oxidation products. Each lot is supplied free of N-oxide impurities, as confirmed by LC–MS analysis.\u003c\/p\u003e","brand":"Polymorphic Lipids","offers":[{"title":"100 mg","offer_id":46550151692449,"sku":"PL-SM102-100MG","price":0.0,"currency_code":"CAD","in_stock":true},{"title":"1 g","offer_id":46550151725217,"sku":"PL-SM102-1G","price":0.0,"currency_code":"CAD","in_stock":true},{"title":"Custom","offer_id":46550151790753,"sku":"PL-SM102-CUSTOM","price":0.0,"currency_code":"CAD","in_stock":true}],"url":"https:\/\/peaklipids.com\/products\/sm-102","provider":"Peak Lipids","version":"1.0","type":"link"}